Why the study?
Does disruption of lymphatic drainage impair reverse cholesterol transport in mouse models?
Does disruption of lymphatic drainage impair reverse cholesterol transport in mouse models?
Answers are grounded in this paper and cite their sources.
This commentary highlights preclinical evidence that lymphatic vasculature is essential for reverse cholesterol transport from atherosclerotic plaques, identifying it as a potential therapeutic target for atherosclerotic vascular disease.
Reverse cholesterol transport (RCT) is the pathway by which cholesterol accumulated in peripheral tissues, including the artery wall, is transported to the liver for excretion. There is strong evidence suggesting that interventions that increase macrophage cholesterol efflux and RCT would be antiatherogenic. In this issue of the JCI, Martel et al. investigate the contribution of lymphatic vasculature to RCT. Their results support the concept that the lymphatic vessel route is critical for RCT from atherosclerotic plaques. Therefore, strategies to improve lymphatic transport might be useful for treating atherosclerotic vascular disease.
No takes yet. Share an insight, caveat, or question.
Carlos Fernández‐Hernando (2013) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: