Three transposable elements exhibiting differential expression in pre-eclampsia overlap with enhancer regions

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Transposable elements (TEs) play a crucial role in placental development and dysfunction. Our study examined TE expression in pre-eclampsia (PE) using RNA-seq datasets. We identified differentially expressed TEs and explored the genomic location of the most significant TEs, investigating their possible regulatory roles. Notably, three TEs overlapped with putative enhancer regions, suggesting a potential regulatory impact on gene expression. These findings highlight the regulatory potential of TEs and their importance in placental development, supporting that TE dysregulation may contribute to PE pathogenesis. • Transposable element dysregulation is a feature of pre-eclampsia. • Upregulated transposable elements in pre-eclampsia show overlap with enhancers. • Transposable element upregulation in pre-eclampsia suggests regulatory roles. • Dysregulated transposable elements reveal potential diagnostic/therapeutic targets.