November 11, 1985FEBS Letters

Calcium‐activated, phospholipid‐dependent protein kinase in cultured rat mesangial cells

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Population

Cultured rat glomerular mesangial cells

Design

Preclinical

Authors

YOYoshimasa OritaOsaka Institute of Technology YFYoshihiro FujiwaraJapan Agency for Marine-Earth Science and Technology SOSatoshi OchiJikei University School of Medicine

Discussion

Member takes

Implication

May link angiotensin II to PKC activation in mesangial cells; hypothesis-generating and requires in vivo validation.

Structured PICO

Population

Cultured rat glomerular mesangial cells

Intervention

Angiotensin II (10(-6)M)

Outcome

Hydrolysis of phosphatidylinositol 4,5-bisphosphate and production of diacylglycerolsurrogate

Activation of protein kinase C via phosphoinositide metabolism may be an important intracellular regulatory mechanism of angiotensin II in cultured mesangial cells.

Cite This Study

Orita et al. (1985) studied this question.

synapsesocial.com/papers/6a7f8ca6f237f9a090acb676 https://doi.org/10.1016/0014-5793(85)80063-6

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