Retinol-Binding Protein 4, Insulin Resistance, and Type 2 Diabetes

The current pandemic of type 2 diabetes is closely associated with obesity and insulin resistance. It is therefore essential that we gain a greater understanding of the pathogenesis of these two conditions and develop new approaches for their prevention and treatment.The physiological changes responsible for the clinical manifestations of type 2 diabetes have been well characterized and include the defective secretion of insulin, enhanced hepatic glucose production, resistance to the action of insulin in its target tissues (muscle, fat, and liver), and elevated levels of triglyceride-rich particles and free fatty acids. All these abnormalities are generally present in clinically . . .