Kaposi sarcoma ( KS ) is an unusual vascular tumour caused by an oncogenic‐herpesvirus, Kaposi sarcoma‐associated herpesvirus ( KSHV ), also known as human herpesvirus 8 ( HHV 8). KS lesions are characterized by an abundant inflammatory infiltrate, the presence of KSHV ‐infected endothelial cells that show signs of aberrant differentiation, as well as faulty angiogenesis/ vascularization. Here we discuss the molecular mechanisms that lead to the development of these histological features of KS , with an emphasis on the viral proteins that are responsible for their development.
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Gramolelli et al. (2014) studied this question.
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