Why the study?
Is baroreflex sensitivity impaired in subjects with treated recurrent depression in remission compared to healthy controls?
Population
75 subjects. Exclusion criteria: manifest heart disease, smoking, hypertension, diabetes…
Comparison
Treated recurrent depression (exposure) vs Healthy controls
Design
Case-control
Authors
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Hypothesis-generating for baroreflex impairment as CV risk mechanism in depression; prospective studies needed to confirm.
Is baroreflex sensitivity impaired in subjects with treated recurrent depression in remission compared to healthy controls?
Baroreflex sensitivity is impaired in otherwise healthy patients with treated recurrent depression, suggesting a potential mechanism for increased cardiovascular risk in this population.
Broadley et al. (2005) studied this question.
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