What question did this study set out to answer?

To determine whether extending oral anticoagulant therapy from one month to six months reduces the risk of recurrent symptomatic deep vein thrombosis.

January 12, 1985Acta Medica Scandinavica

One‐Month versus Six‐Month Therapy with Oral Anticoagulants after Symptomatic Deep Vein Thrombosis

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Why the study?

Does one month of oral anticoagulants compared to six months reduce the recurrence of symptomatic DVT in patients with first period DVT?

Population

135 patients with symptomatic first period deep vein thrombosis (DVT) (83% with proximal DVT)

Comparison

Oral anticoagulants for one month vs Oral anticoagulants for six months

Design

RCT, Randomly allocated

Follow-up

at least one year

Authors

KHK HolmgrenKarolinska University Hospital BFB FagrellKarolinska Institutet HJHans JohnssonKarolinska University Hospital

Discussion

Member takes

Implication

High recurrence after first DVT persists irrespective of one- versus six-month anticoagulation; challenges extension of therapy and extends evidence favoring shorter courses.

Key Points

To determine whether extending oral anticoagulant therapy from one month to six months reduces the risk of recurrent symptomatic deep vein thrombosis.
Randomized trial involving 135 patients with a first episode of symptomatic deep vein thrombosis (83% proximal DVT) allocated to either one month or six months of oral anticoagulants.
Initial and recurrent events were confirmed by phlebography, plethysmography, thermography, lung scans, or autopsy, with patient follow-up lasting at least one year.
Symptomatic recurrence occurred in 17% of patients during the first year of follow-up, with rates remaining similar irrespective of one-month or six-month therapy duration.
One patient stopped treatment prematurely due to hemorrhage, and 17 patients discontinued the trial for other reasons (10 during therapy and 7 post-therapy).

Structured PICO

Does one month of oral anticoagulants compared to six months reduce the recurrence of symptomatic DVT in patients with first period DVT?

Population

135 patients with symptomatic first period deep vein thrombosis (DVT) (83% with proximal DVT)

Intervention

Oral anticoagulants for one month

Comparator

Oral anticoagulants for six months

Outcome

Symptomatic recurrence of DVT or pulmonary emboli during the first yearhard clinical

One month of oral anticoagulation therapy resulted in a similarly high recurrence rate (17%) of symptomatic DVT compared to six months of therapy during the first year of follow-up.

Cite This Study

Holmgren et al. (1985) studied this question.

synapsesocial.com/papers/6a7faaaeeddba99f883e8994 https://doi.org/10.1111/j.0954-6820.1985.tb06125.x

Topics

Anticoagulation in AF

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Implication

High recurrence after first DVT persists irrespective of one- versus six-month anticoagulation; challenges extension of therapy and extends evidence favoring shorter courses.

One‐Month versus Six‐Month Therapy with Oral Anticoagulants after Symptomatic Deep Vein Thrombosis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

One‐Month versus Six‐Month Therapy with Oral Anticoagulants after Symptomatic Deep Vein Thrombosis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider