Abstract of cultured rabbit renal cortical cells containing more than 50% of proximal tubular cells have been investigated. It was consequently found that epidermal growth factor exhibited the most potent growth promoting activity. In addition, insulin-like growth factor-I and acidic and basic fibroblast growth factor also stimulated the growth of cultured tubular cells, though no effect was observed in platelet derived growth factor. In contrast, transforming growth factor-β was found to be the only growth inhibitor of the tubular cells in the presence of insulin or fibroblast growth factor.
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Kanda et al. (1989) studied this question.
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