Growth and Liver Response of Chicks and Rats to Carbon Tetrachloride and Ethanol

THE effects of CCl4 and ethanol in such mammals as mice, rats, rabbits and guinea pigs have been described in great detail (Hove, 1949; Tsuboi and Stowell, 1951; Recknagel and Litteria, 1960; Dinman et al., 1963; Judah et al., 1965; Smuckler et al., 1965; Mirone, 1965; Di Luzio, 1966). These two agents have been shown to induce fat and necrosis in livers in these animals. The mechansim for producing these effects has been a subject of considerable study for at least 20 years. It has been postulated that the fat accumulation in the liver cell induced by CCl4 is due to an impairment of the cell’s ability to secrete triglycerides, which, in turn, is possibly due to an impairment of lipoprotein synthesis (Heimberg et al., 1962, 1965). The fat accumulation induced by ethanol has been partially attributed to an increased mobilization of fat from adipose tissue and a decreased oxidation…