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January 1, 1992The Journal of AntibioticsOpen Access

Synthesis of 1233A analogs and their inhibitory activity against hydroxymethylglutaryl coenzyme A synthase.

Toshiaki Sunazuka Kazuo Tsuzuki HIDETOSHI KUMAGAI Hiroshi Tomoda Haruo Tanaka Hajime Nagashima Hirokazu Hashizume Satoshi Ōmura

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Abstract

Simple and efficient syntheses of 1233A analogs were developed and the inhibitory activity of the analogs against hydroxymethylglutaryl coenzyme A (HMG-CoA) synthase was determined. Study of the structure-activity relationships revealed that not only the geometry in beta-lactone moiety but also the length of the carbon side chain is important for inhibitory activity against HMG-CoA synthase.

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Sunazuka et al. (1992) studied this question.

synapsesocial.com/papers/6a7fe07b4fa3c9b321b9b021 https://doi.org/10.7164/antibiotics.45.1139

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