Modern management of myasthenia gravis has markedly improved prognosis in instances of crisis and has made thymectomy a safe and essentially uneventful procedure. A small core of patients with refractory myasthenia unresponsive to drug adjustment, adjuvant medication, and thymectomy occupy, today, the bulk of hospital beds for this disease. In an attempt to solve this problem 25 short-term courses of corticotropin as a single or "paired" course were administered in massive dosage to 11 hospitalized patients, with gratifying results.
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Kermit E. Osserman (1966) studied this question.
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