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Controlled physiological study demonstrates impaired renal water conservation in elderly males, indicating reduced homeostatic capability during water deprivation.
The hallmark of aging is a progressive decrease in homeostatic capability — a decreased response to an internal or external environmental perturbation. The article by Phillips and associates* in this issue of the Journal provides a clear example of this phenomenon.Phillips et al. report that after a 24-hour period of restricted water intake, an equal weight loss occurred in a group of elderly male subjects and a group of young male controls. The older group had greater increases in plasma sodium osmolality and arginine vasopressin concentrations. Despite these higher concentrations, the elderly elaborated a less concentrated urine and experienced . . .
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Alexander Leaf (1984) studied this question.
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