Key result
Sibling stroke history linked to ~2-fold higher odds of severe deficit after ischemic stroke.
Why the study?
A family history of stroke is an independent risk factor for stroke, but whether a family history of stroke is associated with the severity of neurologic deficit after stroke was unknown.
Is a family history of stroke in first-degree relatives associated with the severity of neurologic deficit in patients with first-ever symptomatic ischemic stroke?
Observational (n=505)
Yes
Is a family history of stroke in first-degree relatives associated with the severity of neurologic deficit in patients with first-ever symptomatic ischemic stroke?
In patients with first-ever symptomatic ischemic stroke, having a sibling history of stroke is independently associated with a twofold higher odds of experiencing a more severe neurologic deficit (NIHSS ≥5), whereas parental or offspring stroke history is not.
Background A family history of stroke is an independent risk factor for stroke. Objective To assess whether severity of neurologic deficit after stroke is associated with a family history of stroke. Methods The Ischemic Stroke Genetics Study, a five-center study of first-ever symptomatic ischemic stroke, assessed case subjects prospectively for a family history of stroke-affected first-degree relatives. Certified adjudicators used the NIH Stroke Scale (NIHSS) to determine the severity of neurologic deficit. Results A total of 505 case subjects were enrolled (median age, 65 years; 55% male), with 81% enrolled within 1 week of onset of symptoms. A sibling history of stroke was associated with more severe stroke. The odds of an NIHSS score of 5 or higher were 2.0 times greater for cases with a sibling history of stroke compared with cases with no sibling history (95% CI, 1.0 to 3.9). An association of family history of stroke in parents or children with stroke severity was not detected. Conclusions A sibling history of stroke increased the likelihood of a more severe stroke in the case subjects, independent of age, sex, and other potential confounding factors. Other family history characteristics were not associated with stroke severity.
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Meschia et al. (2006) conducted an observational in First-ever symptomatic ischemic stroke (n=505). Sibling history of stroke vs. No sibling history of stroke was evaluated on Severity of neurologic deficit (NIH Stroke Scale [NIHSS] score of 5 or higher) (OR 2.0, 95% CI 1.0-3.9). A sibling history of stroke was associated with double the odds of a severe neurologic deficit (NIHSS ≥5; OR 2.0; 95% CI, 1.0 to 3.9) after first-ever ischemic stroke.
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