The study characterizes a myc-containing retrovirus generated by propagation of an MH2 viral subgenomic RNA, providing insights into viral oncogene expression.
Provides animal model for myc oncogene study without v-mil; leaves open subgenomic RNA roles in retroviral oncogenesis.
We have previously isolated, from wild-type MH2 virus that contains the two oncogenes mil and myc, mutants defective in one or the other oncogene product. We report here the molecular cloning and extensive characterization of MH2 CL25 provirus lacking the v-mil oncogene. Our results indicate that this virus corresponds to the propagation of the 2.8-kilobase subgenomic RNA of MH21.
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Martin et al. (1986) studied this question.
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