A variety of cell types may be infected and trans-formed by Rous sarcoma virus (RSV) in vitro. These transformed cells lose the particular cell products that characterize them as particular cell types. Myoblasts transformed by RSV fail to fuse and to synthesize a variety of muscle-specific products (Holtzer t al. 1975; Fiszman and Fuchs 1975). Chondroblasts undergo a qualitative shift in the particular species of sulfated proteoglycan synthesized (Pacifici et ai. 1977). Retinal melanoblasts destroy their melanosomes and stop synthesis of melanin (Boettiger et al. 1977). In each case examined, cell populations were infected and then examined at a time when they xpress their definitive phenotypes. The process of transformation by RSV suppresses the expression of the differentiated cell
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Boettiger et al. (1980) studied this question.