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August 15, 2026NeurophotonicsOpen Access

Cedalion tutorial: a Python-based framework for comprehensive analysis of multimodal fNIRS and DOT from the lab to the everyday world

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Authors

EMEike MiddellLCLaura CarltonSMShakiba Moradi

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Overview

Software tutorial presents an open-source Python platform for multimodal fNIRS and optical tomography, highlighting reproducible and machine learning-ready neuroimaging workflows.

Key Points

  • To introduce Cedalion, a standardized open-source Python framework designed to unify model-based and machine-learning-driven analyses of multimodal fNIRS and diffuse optical tomography data.
  • Integrated forward modeling, photogrammetric coregistration, motion correction, general linear model analysis, and diffuse optical tomography reconstruction within the standard Python scientific stack.
  • Engineered compatibility with SNIRF and BIDS data standards alongside interfaces for scikit-learn and PyTorch to support multimodal fusion with electroencephalography, magnetoencephalography, and physiological streams.
  • Constructed seven fully executable, containerized Jupyter tutorial notebooks with continuous integration testing and automated citation tracking.
  • Unified fragmented analytical pipelines into a reproducible, cloud-executable architecture for both laboratory and real-world wearable optical neuroimaging.
  • Enabled end-to-end execution of complex workflows spanning signal quality assessment, data augmentation, multimodal physiological analysis, and 3D tomographic image reconstruction.

Cite This Study

Middell et al. (2026) studied this question.

synapsesocial.com/papers/6a80197375c2e31742c856e2https://doi.org/10.1117/1.nph.13.s3.s32602
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