Experimental study demonstrates that the developing intestine regulates systemic growth during nutrient deficiency, indicating gut-mediated metabolic control.
Key Points
To elucidate how the developing intestine senses nutritional deprivation and microbiome cues to regulate organismal growth.
Assessed organismal growth responses under varying nutritional conditions and microbiome compositions.
Investigated intestinal and enteroendocrine signaling mechanisms that monitor nutrient availability.
Identified the developing intestine as a primary sensor and central regulator coordinating systemic body growth.
Showed that intestinal signaling alters developmental growth trajectories in response to nutritional shortages and microbiome status.