The gut takes it all: Enteroendocrine control of developmental growth

Julia B. Cordero

doi:10.1371/journal.pbio.3003921

August 12, 2026PLoS BiologyOpen Access

The gut takes it all: Enteroendocrine control of developmental growth

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Key Points

To elucidate how the developing intestine senses nutritional deprivation and microbiome cues to regulate organismal growth.
Assessed organismal growth responses under varying nutritional conditions and microbiome compositions.
Investigated intestinal and enteroendocrine signaling mechanisms that monitor nutrient availability.
Identified the developing intestine as a primary sensor and central regulator coordinating systemic body growth.
Showed that intestinal signaling alters developmental growth trajectories in response to nutritional shortages and microbiome status.

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Implication

Experimental study demonstrates that the developing intestine regulates systemic growth during nutrient deficiency, indicating gut-mediated metabolic control.

Abstract

How developing animals sense nutritional shortages to adjust growth?A new study in PLOS Biology shows that the developing intestine is a central regulator of animal growth in response to microbiome composition and nutritional deficiency.

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Cite This Study

Julia B. Cordero (2026) studied this question.

synapsesocial.com/papers/6a80197375c2e31742c85877 https://doi.org/10.1371/journal.pbio.3003921

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The gut takes it all: Enteroendocrine control of developmental growth

Key Points

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Implication

Abstract

Discussion

Cite This Study

The gut takes it all: Enteroendocrine control of developmental growth

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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