Recent Advances: Early Diagnosis and Early Treatment of Secondary Lymphedema Following Cancer Therapy, and Emerging Roles of Lymphatic Ultrasound

Makoto Mihara; Hisako Hara; Yohei Iwanaga; Mari Kawahara

doi:10.7134/phlebol.25-12

August 12, 2026The Japanese Journal of PhlebologyOpen Access

Recent Advances: Early Diagnosis and Early Treatment of Secondary Lymphedema Following Cancer Therapy, and Emerging Roles of Lymphatic Ultrasound

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Key Points

To review recent advances in diagnostic imaging, particularly lymphatic ultrasound, and early intervention strategies for secondary lymphedema following cancer therapy.
Narrative synthesis of clinical evidence evaluating diagnostic modalities, including lymphoscintigraphy, indocyanine green (ICG) lymphography, and high-resolution ultrasound.
Assessment of therapeutic pathways combining conservative management with early lymphaticovenular anastomosis (LVA).
Imaging abnormalities precede subjective symptoms and limb circumference enlargement, demonstrating that conventional circumference measurements delay early diagnosis.
Non-invasive lymphatic ultrasound provides high-sensitivity visualization of collecting lymphatic vessels to assist diagnosis, preoperative planning, and follow-up.
Early implementation of lymphaticovenular anastomosis alongside conservative therapy suppresses chronic progression and reduces the incidence of cellulitis.

Implication

Clinical review highlights advances in lymphatic imaging and early surgical intervention for post-cancer secondary lymphedema, indicating improved outcomes and prevention of disease progression.

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Cite This Study

Mihara et al. (2026) studied this question.

synapsesocial.com/papers/6a80197375c2e31742c85888 https://doi.org/10.7134/phlebol.25-12

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Recent Advances: Early Diagnosis and Early Treatment of Secondary Lymphedema Following Cancer Therapy, and Emerging Roles of Lymphatic Ultrasound

Key Points

Implication

Abstract

Discussion

Cite This Study

Recent Advances: Early Diagnosis and Early Treatment of Secondary Lymphedema Following Cancer Therapy, and Emerging Roles of Lymphatic Ultrasound

Key Points

Implication

Abstract

Discussion

Cite This Study

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