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August 15, 2026Arquivos de Neuro-PsiquiatriaOpen Access

Functional neurological disorder: characterization, diagnosis, and outcome predictors in a Brazilian cohort

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Authors

LDLucas D'AndreaAAAntônio Paulo Rinaldi AsciuttiJDJordana Borges C. Diniz

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Overview

Retrospective cohort study reveals predictors of clinical improvement in patients with functional neurological disorder, highlighting the benefit of multidisciplinary interventions.

Key Points

  • Describe the clinical profile of patients with functional neurological disorder and identify predictors of functional improvement in an outpatient setting.
  • Retrospectively analyzed medical records of N = 29 patients diagnosed with functional neurological disorder using DSM-5 criteria at an outpatient unit in Brazil.
  • Recorded clinical features, psychiatric comorbidities, and therapeutic interventions, and modeled predictors of functional improvement using multivariable Firth's bias-reduced logistic regression.
  • Overall, 31% of patients achieved functional improvement, with pain (51.7%) and paresis (48.3%) representing the most common clinical presentations.
  • Group psychotherapy with a psychodynamic orientation (p = 0.036) and eutony (OR = 5.68; p < 0.05) were significantly associated with increased odds of functional improvement.
  • Absence of mood disorders was associated with reduced odds of functional improvement (OR = 0.36; 95% CI: 0.11–0.99; p = 0.048).

Cite This Study

D'Andrea et al. (2026) studied this question.

synapsesocial.com/papers/6a8019bb75c2e31742c85caehttps://doi.org/10.1055/s-0046-1827064
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