Narrative review reveals substantial corrinoid composition diversity across edible shellfish species, highlighting that nutritional value depends on active molecular forms rather than total...
In edible shellfish, vitamin B12 content has traditionally been evaluated based on total content; however, recent studies reveal substantial diversity in corrinoid composition among species. This review integrates molecular and ecological perspectives to reassess vitamin B12 levels in shellfish using cobamide fingerprinting. Filter-feeding bivalves generally exhibit vitamin B12-dominant profiles, whereas herbivorous gastropods often contain higher proportions of pseudovitamin B12, and carnivorous species display intermediate or vitamin B12-dominant patterns reflecting trophic transfer. In addition, physicochemical form and food processing influence vitamin B12 bioavailability. These findings collectively demonstrate that a precise nutritional assessment requires a comprehensive evaluation of both the total content and the molecular makeup of corrinoids.
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Watanabe et al. (2026) studied this question.
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