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August 15, 2026Translational Animal ScienceOpen Access

Effects of increasing trypsin inhibitor on nursery pig growth performance, fecal dry matter, and nutrient digestibility

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Authors

SCSierra M CollierPSPaige T. SoperKGK. Gaffield

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Overview

Randomized trial demonstrates that increasing dietary trypsin inhibitors reduces growth performance and protein digestibility in nursery pigs, indicating a need to limit soy antinutrients.

Key Points

  • To evaluate the effects of increasing trypsin inhibitor units in complete feed on growth performance, fecal dry matter, and nutrient digestibility in nursery pigs.
  • Randomized 360 weanling barrows (initially 6.1 ± 0.03 kg; 12 pens per treatment, 5 pigs per pen) to six dietary treatments with 1.4, 2.1, 2.8, 3.5, 4.2, and 4.9 TIU/mg of complete feed across a 42-day, three-phase trial.
  • Formulated diets by adding soy flour (76 TIU/mg) at the expense of soybean meal (5.4 TIU/mg).
  • Measured growth performance, fecal dry matter (DM) on days 10 and 42, and apparent total tract digestibility (ATTD) of DM and crude protein (CP) on day 42.
  • Increasing dietary TIU linearly decreased overall (d 0 to 42) average daily gain (ADG; P < 0.001), average daily feed intake (ADFI; P < 0.001), and gain-to-feed ratio (G:F; P < 0.001).
  • Each 1 TIU/mg increase was associated with a 38 g/d (7.4%) reduction in ADG, a 40 g/d (5%) reduction in ADFI, and an approximate 3% decrease in G:F.
  • ATTD of CP decreased linearly (P < 0.001) as TIU increased, while ATTD of DM showed a quadratic response (P = 0.003), reaching its lowest point at 4.2 TIU/mg.

Cite This Study

Collier et al. (2026) studied this question.

synapsesocial.com/papers/6a8019ce75c2e31742c85f95https://doi.org/10.1093/tas/txag126
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