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Identify the most effective incident projectile and target materials for producing critical medical isotopes, including 225Ac and 99Mo, using a heavy-water-cooled thick spallation target.

August 15, 2026Nuclear Science and Engineering0 citations

Monte Carlo Simulation of Medical Isotope Production Using Thorium and Uranium Targets

Monte Carlo Simulation of Medical Isotopes Production by Irradiation of nat U and 232 Th Targets with P, α, 9 Be and 12 C

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Authors

QLQiuying Liang TLTiancheng Lai GYGuanghui Yang

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Overview

Simulation study demonstrates enhanced medical isotope yields from beryllium-9 irradiation of thorium targets, suggesting more efficient production strategies for targeted radiotherapies.

Key Points

Identify the most effective incident projectile and target materials for producing critical medical isotopes, including 225Ac and 99Mo, using a heavy-water-cooled thick spallation target.
Designed a water-cooled thick spallation target incorporating heavy water with thorium metal particles (232Th + D2O) or uranium metal particles (natU + D2O) to optimize heat dissipation and yield.
Utilized the PHITS (Particle and Heavy Ion Transport Code System) Monte Carlo code to model and compare beam energies, projectiles (protons, alpha particles, 9Be, 12C), isotope yields, secondary particle fluxes, and energy deposition.
Irradiation with 9Be achieved the highest isotope yields among tested projectiles due to increased generation of high-flux secondary neutrons, despite an associated increase in energy deposition.
Thorium-232 targets consistently demonstrated higher isotope yields and lower energy deposition than natural uranium targets under identical irradiation conditions.

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Cite This Study

Liang et al. (2026) studied this question.

synapsesocial.com/papers/6a801a1a75c2e31742c86a1b https://doi.org/10.1080/00295639.2026.2707586

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August 15, 2026Nuclear Science and Engineering0 citations

Monte Carlo Simulation of Medical Isotope Production Using Thorium and Uranium Targets

Monte Carlo Simulation of Medical Isotopes Production by Irradiation of nat U and 232 Th Targets with P, α, 9 Be and 12 C

View Full Paper

Authors

QLQiuying Liang TLTiancheng Lai GYGuanghui Yang

Discussion

Member takes

Overview

Simulation study demonstrates enhanced medical isotope yields from beryllium-9 irradiation of thorium targets, suggesting more efficient production strategies for targeted radiotherapies.

Key Points

Identify the most effective incident projectile and target materials for producing critical medical isotopes, including 225Ac and 99Mo, using a heavy-water-cooled thick spallation target.
Designed a water-cooled thick spallation target incorporating heavy water with thorium metal particles (232Th + D2O) or uranium metal particles (natU + D2O) to optimize heat dissipation and yield.
Utilized the PHITS (Particle and Heavy Ion Transport Code System) Monte Carlo code to model and compare beam energies, projectiles (protons, alpha particles, 9Be, 12C), isotope yields, secondary particle fluxes, and energy deposition.
Irradiation with 9Be achieved the highest isotope yields among tested projectiles due to increased generation of high-flux secondary neutrons, despite an associated increase in energy deposition.
Thorium-232 targets consistently demonstrated higher isotope yields and lower energy deposition than natural uranium targets under identical irradiation conditions.

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View Full Paper

Cite This Study

Liang et al. (2026) studied this question.

synapsesocial.com/papers/6a801a1a75c2e31742c86a1b https://doi.org/10.1080/00295639.2026.2707586

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View Full Paper