Bioinformatic analysis reveals CTDNEP1 upregulation correlates with poor glioblastoma survival, indicating its potential as a prognostic biomarker.
Key Points
To investigate the expression, clinical significance, and functional pathways associated with CTD nuclear envelope phosphatase 1 (CTDNEP1) in glioblastoma.
Analyzed transcriptomic and clinical data from The Cancer Genome Atlas using differential expression, Kaplan–Meier survival, and Cox regression analyses.
Conducted gene set enrichment, KEGG pathway, and Gene Ontology analyses to identify CTDNEP1-related signaling pathways.
Evaluated single-cell RNA sequencing datasets and used CIBERSORT to examine cellular distribution and immune cell infiltration within the tumor microenvironment.
CTDNEP1 expression is significantly elevated in glioma tissues, positively correlates with tumor grade, and independently predicts poor overall survival.
Functional enrichment showed CTDNEP1 co-expressed genes are linked to neuronal signaling, ion channel activity, and cell cycle regulation.
Single-cell and CIBERSORT analyses demonstrated that CTDNEP1 is predominantly expressed in tumor and myeloid cells and associates with distinct immune cell infiltration patterns.