Preinfection of chick embryo fibroblasts with an avian tumor virus does not eliminate the requirement of early DNA synthesis for other avian tumor viruses superinfecting the same cells several days after the primary inoculum. The function served by the early DNA in avian tumor virus infection either fails to persist into late infection or is genetically specific for each viral type.
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Duesberg et al. (1969) studied this question.
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