Why the study?
Does vasopressin treatment affect angiotensin-converting enzyme activity in the pituitary lobes of Brattleboro rats?
Does vasopressin treatment affect angiotensin-converting enzyme activity in the pituitary lobes of Brattleboro rats?
These findings suggest an inverse relationship between the vasopressin and angiotensin systems in the posterior and intermediate lobes of the pituitary gland.
Preclinical finding in rats; leaves open whether vasopressin-ACE interactions translate to human pituitary function.
The activity of angiotensin-converting enzyme is significantly higher in the intermediate and posterior pituitary lobes of Brattleboro rats than in Long-Evans control rats. The high activity level was reversed by vasopressin treatment. Conversely, angiotensin-converting enzyme activity was significantly lower in the anterior pituitary of Brattleboro rats than in Long-Evans rats, and this activity level was not affected by vasopressin. these findings suggest an inverse relation between vasopressin and angiotensin systems in the posterior and intermediate lobes of the pituitary gland.
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Chevillard et al. (1982) studied this question.