The time dependence of thallium influx indicates that thallium scintigraphy of the myocardium reflects mainly an extracellular distribution.
Caution advised in thallium scintigraphy interpretation; animal data leaves open human kinetic translation.
Although myocardial scintigraphy with 201thallium is widely applied in humans, the behavior of thallium at the cellular level is still under discussion. We compared the transmembrane fluxes of potassium and thallium in the isolated papillary muscle of guinea pigs. A qualitative conformity exists between potassium and thallium fluxes with respect to heart rate and temperature. Quantative comparison revealed a decreased flux rate of thallium for efflux when compared with potassium. The time dependence of thallium influx indicates that thallium scintigraphy of the myocardium reflects mainly an extracellular distribution.
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Nitsch et al. (1980) studied this question.
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