Why the study?
Oncocytic adrenocortical carcinoma is a rare variant of adrenocortical carcinoma whose paradoxical indolent biological behavior makes diagnosis and management challenging.
Design
Case report and literature review
Key result
In a 45-year-old female with a 24 cm oncocytic adrenocortical carcinoma, multiorgan surgical resection followed by radiation resulted in no evidence of tumor recurrence at three months.
Authors
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Favorable short-term outcome should not yet change practice; leaves open prognostic implications of oncocytic histology despite high-risk features.
Case Report (n=1)
A large oncocytic adrenocortical carcinoma with necrosis and venous invasion can exhibit an indolent clinical course and favorable molecular profile, highlighting a clinical paradox where size does not always predict poor prognosis.
Ojha et al. (2025) conducted a case report in Oncocytic adrenocortical carcinoma (n=1). Surgical resection and external beam radiation therapy was evaluated on Tumor recurrence. In a 45-year-old female with a 24 cm oncocytic adrenocortical carcinoma, multiorgan surgical resection followed by radiation resulted in no evidence of tumor recurrence at three months.