Key result
In patients with Takotsubo syndrome, hyperleukocytosis was an independent predictor of adverse in-hospital events (OR 1.04), alongside dyspnea on admission, neurological triggers, and lower ejection fraction.
Why the study?
Given seasonal variation seen in air pollution, inflammation, and coronary events, this study investigated whether chronobiology and inflammation contribute to adverse outcomes in takotsubo syndrome.
Does seasonal variation and inflammation predict adverse outcomes in patients with Takotsubo syndrome?
Cohort (n=559)
Yes
Does seasonal variation and inflammation predict adverse outcomes in patients with Takotsubo syndrome?
In patients with Takotsubo syndrome, occurrence during winter and spring, along with higher inflammatory burden and neurological triggers, independently predicts worse in-hospital outcomes and 30-day mortality.
May support seasonal risk awareness and inflammation monitoring in TTS; leaves open causal mechanisms and prospective interventional testing.
BACKGROUND: Initially regarded as a benign acute cardiomyopathy, recent insights have shown that takotsubo syndrome (TTS) carries a prognosis comparable to that of acute coronary syndrome, with a notable impact of inflammatory burden. Given the seasonal variation seen in air pollution, inflammation, and coronary events, we investigated whether chronobiology and inflammation contribute to adverse outcomes. METHODS AND RESULTS: Between 2008 and 2020, all consecutive TTS patients were retrospectively included in a multicenter registry. We analyzed the impact of seasonal variation and inflammation on in-hospital events, including acute cardiac failure, cardiogenic shock, and death, as well as 30-day mortality. In-hospital events were identified in 238 (42.6%) patients. Higher rates of in-hospital events and 30-day mortality were observed during winter and spring than in summer and autumn. Multivariate analysis identified the presence of dyspnea on admission (odds ratio [OR] 4.02; 95% confidence interval [CI] 2.61-6.17; P<0.001), a neurological trigger (OR 2.58; 95% CI 1.21-5.50; P=0.014), hyperleukocytosis (OR 1.04; 95% CI 1.02-1.17; P=0.002), and left ventricular ejection fraction at admission (OR 0.98; 95% CI 0.96-1.00; P=0.011) as independent predictors of adverse outcomes. CONCLUSIONS: In TTS, higher rates of in-hospital events and 30-day mortality were observed during winter and spring. Inflammatory burden and neurological disorders emerged as independent predictors of poor prognosis.
No takes yet. Share an insight, caveat, or question.
Matsushita et al. (2025) conducted a cohort in Takotsubo syndrome (n=559). Hyperleukocytosis vs. Lower leukocyte count was evaluated on Composite of in-hospital acute heart failure, cardiogenic shock, and in-hospital death (OR 1.04, 95% CI 1.02-1.17, p=0.002). In patients with Takotsubo syndrome, hyperleukocytosis was an independent predictor of adverse in-hospital events (OR 1.04), alongside dyspnea on admission, neurological triggers, and lower ejection fraction.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: