Clinical characteristics and prognostic factors of malignant fibrous histiocytoma of bone: a SEER population-based study

Figures

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  Figure 1. Identification of optimal cut-off points of age at diagnosis (A,B,C) and tumor size (D,E,F) by the X-tile. (A,D) The cut-off points of age at diagnosis and tumor size were determined by the software with the black dots; histograms (B,E) and Kaplan-Meier curves (C,F) were established according to the cut-off points determined. Optimal cut-off points of age at diagnosis and tumor size were 57 years and 66 mm, respectively.

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  Figure 2. Study design. Data of patients with a histologically confirmed diagnosis of MFH-B were extracted from the SEER database (1975–2016), and then were analyzed according to the study design. MFH-B, malignant fibrous histiocytoma of bone; SEER, Surveillance Epidemiology and End Results.

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  Figure 3. Nomograms predicting 3- and 5-year OS (A) and 3- and 5-year CSS (B) of patients with MFH-B. Prognostic factors including age at diagnosis, tumor site, tumor grade, tumor stage, tumor size and surgical treatment had corresponding scores in nomograms. The 3- and 5-year OS rate and CSS rate could be predicted by adding up scores for each factor and connecting to specific survival rate based on the total scores. OS, overall survival; CSS, cancer-specific survival.

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  Figure 4. Internal validation of nomograms to predict OS and CSS. Discrimination: the AUC of the nomograms for 3-year OS (A), 5-year OS (C), 3-year CSS (E) and 5-year CSS (G) were 0.803, 0.810, 0.794 and 0.812, accordingly. Calibration: the calibration plots of the nomograms for 3-year OS (B), 5-year OS (D), 3-year CSS (F) and 5-year CSS (H). OS, overall survival; CSS, cancer-specific survival; AUC, areas under the curve.

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  Figure S1. Kaplan-Meier curves of OS in different groups of age at diagnosis (A), tumor site (B), tumor grade (C), tumor stage (D), tumor size (E) and surgical treatment (F). OS, overall survival.

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  Figure S2. Kaplan-Meier curves of CSS in different groups of tumor site (A), tumor grade (B), tumor stage (C), tumor size (D) and surgical treatment (E). CSS, cancer-specific survival.

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  Figure S3. Kaplan-Meier curves of OS (A) and CSS (B) in patients treated with limb salvage and amputation. OS, overall survival; CSS, cancer-specific survival.

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  Figure S4. Kaplan-Meier curves of OS (A) and CSS (B) before and after 2000. OS, overall survival; CSS, cancer-specific survival.