Oncolytic virus-delivered GSDME: Unlocking pyroptosis to improve dendritic cell function and amplify cytotoxic T cell response

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, it improved tumor control, prolonged survival, and promoted dendritic cell activation and tumor-infiltrating CD8 T cell expansion with cytotoxic phenotypes. Thus, VSV-GP-GSDME combines VSV-GP's oncolytic activity with GSDME-mediated pyroptosis to induce anti-tumor immunity. This dual mechanism broadens applicability across diverse tumors, offering a promising strategy to enhance immunogenicity.