Key result
The LIFESTYLE psychosocial intervention significantly reduced Body Mass Index (MD -0.66) and improved other cardiometabolic and mental health outcomes at one year compared to a control intervention.
Why the study?
To evaluate the efficacy of a six-month psychosocial intervention on metabolic parameters, cardiovascular risk indices, and physical and mental health domains in patients with severe mental disorders.
Does a multicomponent lifestyle behavioral intervention improve BMI, cardiometabolic risk factors, and mental health outcomes in patients with severe mental disorders?
Population
401 patients with schizophrenia, bipolar disorder, or major depression across six Italian University sites
Comparison
Six-month LIFESTYLE psychosocial intervention vs behavioural control intervention
Design
Multicentric randomized controlled trial
Follow-up
One year
Authors
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May support adding structured lifestyle groups in overweight SMI; confirms 6-month benefits persist at 1 year and extends evidence to HOMA-IR.
RCT (n=401)
Single-blind
1:1 ratio
Yes
Does a multicomponent lifestyle behavioral intervention improve BMI, cardiometabolic risk factors, and mental health outcomes in patients with severe mental disorders?
Mean Difference: -0.66 (95% CI -0.99–-0.3)
Absolute Event Rate: 30.1% vs 32.3%
p-value: p=<0.001
A 5-month multicomponent lifestyle behavioral intervention significantly improved BMI, body weight, waist circumference, and insulin resistance at one year in patients with severe mental disorders.
Luciano et al. (2023) conducted an RCT in Severe mental disorders (n=401). LIFESTYLE intervention vs. Brief psychoeducational group intervention (5 sessions) was evaluated on Body Mass Index (BMI) (MD -0.66, 95% CI -0.99 to -0.30, p=<0.001). The LIFESTYLE psychosocial intervention significantly reduced Body Mass Index (MD -0.66) and improved other cardiometabolic and mental health outcomes at one year compared to a control intervention.
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