An electronic hardware model demonstrates that the position of inhomogeneities correlates with abnormal delays and irregularities in signal propagation, mimicking cardiac tissue microstructure.
May link inhomogeneity position to conduction abnormalities; leaves open validation in human arrhythmia models.
In real electrophysiological experiments, irregularities in the extracellular excitation spread are believed to depend on cardiac tissue microstructure. An electronic hardware model was developed to analyze this dependence by placing some inhomogeneities (slow propagation areas) in the medium. The position of such inhomogeneities is correlated with abnormal delays and irregularities measured in signal propagation.
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deCastro et al. (1999) studied this question.
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