Certain disorders, which do not primarily involve the brain, may interfere with its metabolism. If this metabolic dysfunction is sufficiently severe the patient may become confused or even comatose. The continuum from normality to coma will here be considered as one of increasing delirium. Such delirium may be produced by a variety of conditions which include those with alterations in blood chemistry, namely, hypoglycaemia, uraemia, and possibly hypokalaemia (Sherlock, Read, Laidlaw, and Haslam, 1958); certain of the collagen diseases (
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J. Laidlaw (1959) studied this question.
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