Why the study?
While relationships between inflammatory or lipid indexes and atherosclerosis are widely studied, the relationship between the neutrophil to high-density lipoprotein cholesterol ratio and atherosclerosis had not been investigated.
Does an elevated neutrophil to high-density lipoprotein cholesterol ratio (NHR) increase atherosclerosis in a health examination population?
Does an elevated neutrophil to high-density lipoprotein cholesterol ratio (NHR) increase atherosclerosis in a health examination population?
The neutrophil to high-density lipoprotein cholesterol ratio (NHR) is independently associated with atherosclerosis (measured by Ba-PWV) in a nonlinear manner, with a saturation effect observed at a threshold of 3.32.
Answers are grounded in this paper and cite their sources.
Should not yet change atherosclerosis screening; leaves open NHR as a hypothesis-generating early-risk marker needing prospective confirmation.
BACKGROUND: The relationships between inflammatory indexes and atherosclerosis as well as those between blood lipid indexes and atherosclerosis have been widely studied, but the relationship between the neutrophil to high-density lipoprotein cholesterol ratio (NHR) and atherosclerosis had not been investigated until the present study. METHODS: For this cross-sectional study, we continuously collected data from a health examination population in the Second Hospital of Hebei Medical University from January 2012 to December 2017 (N = 1978). The collected data included clinical data, hematological indexes, and brachial-ankle pulse wave velocity (Ba-PWV). Atherosclerosis was defined as Ba-PWV ≥ 1400 cm/s. The relationship between the NHR and atherosclerosis was explored via univariate regression analysis, multivariate regression analysis, smoothing function analysis, and analysis of a threshold saturation effect. RESULTS: Among 1978 participants, the mean age was 54 years, 1189 participants (60.11%) were male, and 1103 (55.76%) had a history of atherosclerosis. Univariate analysis showed a positive association between the NHR and atherosclerosis [odds ratio (OR) = 1.19, 95% confidence interval (CI): 1.11-1.27, P < 0.01], and this positive association remained significant on multivariate analyses with adjustments for confounding factors (OR = 1.14, 95% CI: 1.06-1.24, P < 0.01). Generalized additive model results revealed a non-linear relationship with a saturation effect between the NHR and atherosclerosis, with a threshold at 3.32. At values ≤ 3.32, the NHR was positively associated with atherosclerosis, but the association was not statistically significant for values > 3.32. CONCLUSION: A nonlinear relationship with a certain saturation effect was observed between the NHR and atherosclerosis in a health examination population.
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Zhou et al. (2022) studied this question.
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