Replacement of dichloromethane as the bulk medium within chromatographic purification has been evaluated with a broad range of molecules containing functionality common within Medicinal Chemistry programmes. Analysis of the data set has generated a set of general guidelines to assist in the selection of alternative solvents for CH2Cl2 as the bulk media in these ubiquitously employed processes.
No takes yet. Share an insight, caveat, or question.
Macmillan et al. (2012) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: