Key result
Higher serum albumin is linked to ~5% lower preoperative DVT risk per 1 g/L.
Why the study?
The association between serum albumin level and preoperative deep vein thrombosis in patients aged ≥ 80 years with intertrochanteric fractures remains unclear.
Is lower serum albumin associated with an increased risk of preoperative deep vein thrombosis in patients aged ≥80 years with intertrochanteric fractures?
Observational (n=1,484)
No
Is lower serum albumin associated with an increased risk of preoperative deep vein thrombosis in patients aged ≥80 years with intertrochanteric fractures?
Odds Ratio: 0.95 (95% CI 0.92–0.97)
p-value: p=<0.001
In patients aged 80 and older with intertrochanteric fractures, lower admission serum albumin levels are independently associated with a higher risk of preoperative deep vein thrombosis.
May identify lower preoperative DVT risk in elderly fracture patients with higher albumin; leaves open whether modifying levels affects outcomes.
Objective The association between serum albumin level and preoperative deep vein thrombosis (DVT) in patients aged ≥ 80 years with intertrochanteric fractures remains unclear. This study aimed to examine the association between serum albumin level and preoperative DVT and to explore whether the relationship between serum albumin and DVT exhibits a nonlinear pattern. Methods This retrospective observational study included 1484 consecutive patients aged ≥ 80 years with intertrochanteric fractures who were admitted to our hospital between January 2016 and July 2024. Vital signs, laboratory data, and comorbidities were collected for all participants to examine the association between serum albumin and preoperative DVT. To assess the independent association between serum albumin and DVT, we employed multivariable logistic regression analyses and smooth curve fitting. Subgroup analyses and interaction tests were conducted, followed by sensitivity analyses using propensity score matching. Results A total of 1484 patients aged ≥ 80 years with intertrochanteric fractures were included in the study. After adjusting for potential confounders, each 1 g/L higher serum albumin level was associated with 5% lower odds of preoperative DVT (odds ratio [OR], 0.95; 95% confidence interval [CI], 0.92–0.97, P < 0.01). A linear relationship was observed between serum albumin and preoperative DVT, and participants in the highest quartile of serum albumin had significantly lower preoperative DVT than those in the lowest quartile. Similar patterns were observed in subgroup analyses, with significant interaction effects noted for coronary heart disease, and sensitivity analyses showed that the results were robust. Conclusions Reduced serum albumin concentrations demonstrate a significant association with elevated preoperative DVT in patients aged ≥80 years with intertrochanteric fractures, and further studies are required to confirm this relationship.
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Chen et al. (2026) conducted an observational in Intertrochanteric fractures in patients aged ≥80 years (n=1,484). Serum albumin level vs. Lower serum albumin levels was evaluated on Preoperative deep vein thrombosis (DVT) (OR 0.95, 95% CI 0.92-0.97, p=<0.001). Each 1 g/L higher serum albumin level was associated with a 5% lower odds of preoperative deep vein thrombosis (OR 0.95, 95% CI 0.92-0.97, p<0.001) in patients aged ≥80 years with intertrochanteric fractures.
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