Why the study?
Fentanyl is recommended for prehospital pain management during hemorrhage, but whether it impairs arterial blood pressure regulation and compromises hemorrhagic tolerance was unknown.
Does intravenous fentanyl impair tolerance to simulated hemorrhage in conscious humans?
Comparison
Intravenous fentanyl (75 µg) vs placebo (saline)
Design
Double-blinded randomized placebo-controlled trial
Authors
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Supports fentanyl for prehospital hemorrhage analgesia; first human RCT challenges hypothesized impairment of hemorrhagic tolerance.
Does intravenous fentanyl impair tolerance to simulated hemorrhage in conscious humans?
An analgesic dose of fentanyl does not impair tolerance to simulated hemorrhage or alter blood pressure regulation in conscious humans.
Huang et al. (2021) studied this question.