Why the study?
The study was conducted to explore the relationship between homocysteine levels and cardiac surgery-associated acute kidney injury.
Does elevated serum homocysteine increase the risk of postoperative acute kidney injury in patients undergoing cardiac surgery?
Does elevated serum homocysteine increase the risk of postoperative acute kidney injury in patients undergoing cardiac surgery?
Elevated serum homocysteine is strongly associated with an increased risk of acute kidney injury following cardiac surgery.
Background: To explore the relationship between homocysteine (Hcy) and cardiac surgery-associated acute kidney injury (AKI). Methods: A total of 944 patients who underwent cardiac surgery were enrolled. The association between Hcy levels and the risk of cardiac surgery-associated AKI was evaluated. Results: A total of 135 patients were diagnosed with AKI and the prevalence of AKI was 14.30%. The AKI group had significantly higher levels of Hcy compared with the non-AKI group (16.90 vs 13.56 umol/l; p < 0.001). The incidence rates of AKI increased from 7.2% to 26.72% across increasing Hcy quartiles (p < 0.001). Compared with the first Hcy quartile group, the odds ratio of cardiac surgery-associated AKI was 4.43 (95% CI: 2.27–8.66) in the highest Hcy group. Conclusion: Elevated Hcy level is an independent risk factor for cardiac surgery-associated AKI.
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Li et al. (2024) studied this question.
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