Why the study?
SARS-CoV-2 caused a global pandemic, and its RNA-dependent RNA polymerase (nsp12) is the central component of viral replication machinery and a primary target for remdesivir.
Population
COVID-19 virus full-length nsp12 in complex with cofactors nsp7 and nsp8
Design
Cryo-electron microscopy structural analysis at 2.9-angstrom resolution
Authors
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Should not yet alter remdesivir use; leaves open structure-guided design of superior RdRp inhibitors.
The structure of the SARS-CoV-2 RNA-dependent RNA polymerase provides a basis for the design of new antiviral therapeutics targeting viral RdRp.
Gao et al. (2020) studied this question.
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