Formulation and Evaluation of Quercetin Nanoparticle-Loaded Ointment for Diabetic Foot Wound Healing

A wound healing potential agent of quercetin was isolated from recently harvested onions. The goal of the current research was to create and assess an ointment loaded with quercetin nanoparticles for the successful treatment of diabetic foot wounds. A cold macerated onion powder with DMF had a higher concentration of quercetin which may be able to stop type-I diabetes related seminal vesicle lesions. Primarily, quercetin extract residue-loaded nanoparticles (QNPs-1 to QNPs-5) were formulated by solvent evaporation process and characterized by particle size, zeta potential, drug content, entrapment efficiency, and in-vitro dissolution studies. The QNPs-5 showed better results in particle size (185.5±0.38nm), drug loading (27.84±1.60%), percent entrapment efficiency (85.1±1.63%), and in-vitro release within 240 min (98.90±2.74%) compared to other QNPs formulations. Secondly, Quercetin nanoparticles loaded ointment was prepared by trituration method, and the formulated ointment showed a pleasing look, a silky texture, no phase separation, a yellowish-brown color, and an aromatic odor. The Ex vivo Permeation study showed a maximum of 95.30 ± 4.08% at 240 min and exhibited greater antibacterial activity. This current discovery revealed that the Quercetin nanoparticles loaded ointment might be one of the promised formulations for healing diabetic foot wounds.