Update on the Development of Antagonists of Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTH2). From Lead Optimization to Clinical Proof-of-Concept in Asthma and Allergic Rhinitis

ADVERTISEMENT RETURN TO ISSUEPREVPerspectiveNEXTUpdate on the Development of Antagonists of Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTH2). From Lead Optimization to Clinical Proof-of-Concept in Asthma and Allergic RhinitisRoy Pettipher*† and Mark Whittaker§View Author Information† Oxagen Ltd., 91 Milton Park, Abingdon, Oxon OX14 4RY, U.K.§ Evotec (U.K.) Ltd 114 Milton Park Abingdon Oxon OX14 4SA, U.K.*E-mail: [email protected]. Tel: +44 (0)1235 443328.Cite this: J. Med. Chem. 2012, 55, 7, 2915–2931Publication Date (Web):January 6, 2012Publication History Received18 October 2011Published online13 February 2012Published inissue 12 April 2012https://pubs.acs.org/doi/10.1021/jm2013997https://doi.org/10.1021/jm2013997review-articleACS PublicationsCopyright © 2012 American Chemical SocietyRequest reuse permissionsArticle Views2618Altmetric-Citations69LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Antagonists,Organic acids,Reaction products,Receptors,Rodent models Get e-Alerts