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Chronic treatment of ovariec-tomized female rats with ethynyl estradiol (30 and 72 μg/kg/day) attenuated the increase in tail skin temperature characteristically accompanying sc administration of l-isoproterenol (50, 100, or 200 μg/kg). The mechanism by which the attenuation occurs awaits additional studies.
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Fregly et al. (1978) studied this question.
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