Completing the circle: A synthesis of chromone 3- and 8-carboxamides (3 and 4) from 2-but-2-ynoyl aryl O-carbamates 1 has been achieved via common intermediate 2 in a regioselective manner. Repetitive metalation reactions and an iridium-catalyzed B2pin2 borylation lead to the construction of polysubstituted chromones, which are key components of many bioactive compounds.
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Macklin et al. (2008) studied this question.
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