Transcriptional Evaluation of Antioxidant and Anti-Inflammatory Potential of Buchholzia coriacea in Acetaminophen-Induced Sub-Chronic Renal and Hepatic Toxicity

The aim of this research was to evaluate the possible renal and Hepato-protective effects of ethanolic extract of Buchholzia coriacea seed compared to N-acetylcysteine, on gene expression in the liver and kidneys of Wistar rats subjected to sub-chronic dose of paracetamol. Forty wistar rats were divided into eight groups of five rats in each group. Group 1 received only normal diet as control (CTRL). Groups 2-6 received 14.28 mg/kg body weight of Paracetamol (PM). After 6 hours, 200 mg/kg body weight of extract (E1) was given to group 3, 400 mg/kg body weight extracts (E2) given to group 4, 70 and 150 mg/kg body weight of N-acetylcysteine was administered to group 5 and 6 respectively. Groups 7 and 8 received only 200 and 400 mg/kg body weight of extract (E1 and E2) respectively. This schedule was maintained for 90 days.