Why the study?
The relationship of LA fibrosis with functional changes and thrombus risk in patients with paroxysmal and persistent AF remains unclear.
Thrombus risk in early-stage AF appears driven by LA enlargement and dysfunction, whereas in persistent AF it is more strongly associated with LA stiffening and fibrosis.
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Supports LA fibrosis assessment for thrombus risk in persistent AF; extends stage-specific mechanisms but remains hypothesis-generating.
Kim et al. (2022) studied this question.
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