A case of sinus histiocytosis with massive lymphadenopathy is reported in which the patient had higher than expected antibody titers against the Epstein-Barr (EBV) and rubella viruses. In addition, high anti-EBV titers in family members physically separated suggest an altered immunologic reactivity which could be important in the development of the massive lymphadenopathy associated with this syndrome. The relationship of this syndrome to the EBV along with its histologic characteristics suggest that it may represent a peculiar, late sequelae of infection with this virus, or an atypical manifestations of infectious mononucleosis in an immunologically defective individual.
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Lober et al. (1973) studied this question.
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