[structure: see text] The design of antiparallel coiled-coil heterotrimers with singly mismatched electrostatic interfaces is reported. The new complexes exhibit expected properties for well-formed coiled-coils and have stabilities comparable to those of parallel analogues. The mismatched interface facilitates switching from a parallel to antiparallel complex by pH-triggered strand exchange.
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Schnarr et al. (2005) studied this question.
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