Enterovirus, specifically strains similar to EV-89 and EV-76, was identified as a significant etiologic agent in a 2006 acute encephalitis outbreak in northern India.
Supports enterovirus testing in outbreak encephalitis; leaves open causal confirmation and surveillance needs.
An outbreak of viral encephalitis occurred in northern India in 2006. Attempts to identify an etiologic agent in cerebrospinal fluid by using reverse transcription-PCR showed positivity to enterovirus (EV) in 66 (21.6%) of 306 patients. Sequencing and phylogenetic analyses of PCR products from 59 (89.3%) of 66 specimens showed similarity with EV-89 and EV-76 sequences.
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Sapkal et al. (2009) studied this question.
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