Population
Human adult ventricle tissue and COS-7 cells
Comparison
Expression of KvLQT1 isoform 2 vs Expression of KvLQT1 isoform 1 alone or with IsK
Design
Preclinical
Authors
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Supports isoform-specific IKs regulation in animal myocytes; leaves open relevance to human LQT1.
The identification of a dominant negative isoform of KvLQT1 provides mechanistic insight into the composition and regulation of the delayed rectifier K+ current in cardiac myocytes, relevant to long QT syndrome 1.
Demolombe et al. (1998) studied this question.