The first reaction between 2,4,6‐trichloropyrimidine 1 and anionic nitrogen nucleophiles is described. Treatment of 1 with one equivalent of sodium amide gave mixtures of 4‐amino‐2,6‐dichloropyrimidine 2 and 2‐amino‐4,6‐dichloropyrimidine 3 . Additional quantities of sodium amide failed to provide either diamino‐ or triaminopyrimidines. Instead, the strongly basic nature of sodium amide led to higher molecular products that were not characterized.
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Delia et al. (1999) studied this question.
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